دانشکده علوم پایه دانشگاه مراغه - رضا محمدزاده

نام استاد رضا محمدزاده
گروه آموزشی زیست شناسی
درجه علمی استادیار
تحصیلات دکترا
رشته تحصیلی ژنتیک
محل تحصیل پژوهشگاه ملی مهندسی ژنتیک و بیوتکنولوژی
صفحه اصلی https://science.maragheh.ac.ir/Staff/Reza Mohammadzadeh
آدرس پست الکترونیکی

تماس الکترونیکی

درباره


خوش آمدید

سوابق تحصیلی


- لیسانس زیست شناسی - دانشگاه بوعلی سینا همدان 

- فوق لیسانس سلولی و مولکولی - دانشگاه رازی و پژوهشگاه ملی مهندسی ژنتیک و بیوتکنولوژی 

- دکتری تخصصی ژنتیک مولکولی - پژوهشگاه ملی مهندسی ژنتیک و بیوتکنولوژی
 

 
 

سوابق تدریس


- مهندسی ژنتیک پروکاریوتها- مقطع کارشناسی ارشد رشته ژنتیک و رشته بیوتکنولوژی
- مهندسی ژنتیک یوکاریوتها- مقطع کارشناسی ارشد رشته ژنتیک و رشته بیوتکنولوژی 
- ژنتیک سرطان - مقطع کارشناسی ارشد رشته ژنتیک
- ژنتیک انسانی- مقطع کارشناسی ارشد رشته ژنتیک
- سیتوژنتیک- مقطع کارشناسی ارشد رشته ژنتیک
- ژنتیک مولکولی پزشکی- مقطع کارشناسی رشته زیست فناوری 
- بیولوژی مولکولی- مقطع کارشناسی رشته زیست فناوری و سلولی و مولکولی میکروبی
- بیوتکنولوژی پزشکی- مقطع کارشناسی رشته زیست فناوری

 

زمینه های پژوهشی


Current Research:
  • Targeted delivery of L-Asparaginase II into ALL cells using chitosan-based nanoparticles and studying the expression of apoptosis-related genes (M. Sc thesis-95)
  • Study of simultaneous effect of doxorubicin and miR-34a on induction of apoptosis in T-cell acute lymphoblastic leukemia (T-ALL) (M. Sc thesis-95)
  • Evaluation of pDNA-Loaded chitosan-based nanoparticles for targeted gene delivery to cancer cells toward development of DNA vaccines (M. Sc thesis-95)
  • Chimeric recombinant expression of S1 and HN antigens in Escherichia coli and their formulation by chitosan Nanocomposites toward development of a chimeric nanovaccine against Newcastle disease and infectious bronchitis virus of poultry (M. Sc thesis)
  • Optimizations of targeted gene delivery system into cancer cell based on  acid folic ligand/chitosan Nano composites/anti-cancer drug or gene (M.Sc thesis-95)
  • Analysis of apoptotic pathway genes expression in HL60 Cell Line exposed to Oreganum vulgare nanoparticles (M. Sc thesis - 94)
  • Silencing of bach1and Sail1 gene by small interfering RNA–mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in breast cancer cells (M. Sc thesis-93)
  • Evaluation of colorectal cancer p53 mutation in North West of Iran patients using non-insive method (M. Sc thesis)
  • Designs and constriction of targeted gene delivery system based on chitosan Nano composites (M. Sc thesis-93)
  • Isolation, cloning and expression of Aspergillus niger L-Arginase in Pichia pastoris and immobilization on chitosan nanocomposites (M. Sc thesis-93)
  • Study of mutations in the Androgen Receptor-LBD Gene in Males with Idiopathic Infertility (M. Sc thesis-93)
  • Optimizing the detection method of recombinant Soya and corn oils imported using PCR (M. Sc thesis-92).
  • Isolation, cloning and expression of Bacterial L- Asparaginase genes in Pichiapastoris/ pET system and immobilization in chitosan base nanocomposites (M. Sc thesis-92).
  • Study the association of VDR and NOD2 genes polymorphisms with Parkinson disease using PCR-RFLP techniques in Iranian population (M. SC thesis-91)
  • Molecular characterizations of S1 gene of avian infectious bronchitis virus isolated from layer flocks with nephropathy and urolithiasis in North-east of  Iran (M. Sc thesis - 91)

خلاصه مقالات


Article and Conference Abstracts:
 
Mansoor Aletaha, Masoumeh Sattarivand, Reza Mohammadzadeh*,  Behzad Baradaran*, Post-transcriptional sail1 silencing using siRNA effect the expression level of miR-143, CXCR4 receptors and cell proliferation/growth in MDA_MB-468 cells (submmited in Cancer Biomarker journal. 2017)
Masoumeh Sattarivand, Roghaya Rahmani, Reza Mohammadzadeh*. Investigating the expression level of miR-143 and Matrix of Metalloproteinase-9 (MMP-9) after silencing bach1 gene by siRNA in MDA-MB-468 Cell Line (submmited in Cancer Causes & Control journal. 2017)
Reza Mohammadzadeh*, Mojgan Saeid Harouyan and Seyed Mansour Ale Taha. Silencing of bach1 gene by small interfering RNA–mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells. Tumor Biology, March 2017: 1–11.
Reza Mohammadzadeh*, Maryam Agheshlouie, Gholam Reza Mahdavinia. Expression of Chitinase Gene in BL21 pET system and investigating the biocatalystic performance of Chitinase-loaded AlgSep nanocomposite beads. International journal of biological macromolecules, March 2017, DOI: 10.1016/j.ijbiomac.2017.03.119
Reza Pazhouhesh, Reza Mohammadzadeh*, Nazila Moghtaran. Iran. Conference: 7th International Congress of Biology, Tabriz, Iran. April 2016.
Reza Mohammadzadeh*, Reza Pazhouhesh. Association of VDR FokI and ApaI Genetic Polymorphisms with Parkinson's Disease Risk in South Western Iranian Population.Acta Medica International,  January 2016, DOI: 10.5530/ami.2016.1.24.
Reza Mohammadzadeh, Mostafa Motallebi, Mohamadreza Zamani, Zahra Moghaddassi Jahromi, Peyman Norouzi, Manuel Benedetti, Giulia De Lorenzo. Generation of transgenic sugar beet (Beta vulgarism L.) overexpressing the polygalacturonase inhibiting protein 1 of Phaseolus vulgaris (PvPGIP1) through Agrobacterium-mediated transformation. Turkish Journal of Agriculture and Forestry, January 2015.
Reza Mohammadzadeh, Mohammadreza Zamani, Mostafa Motallebi, Paiman Norouzi, Esmat Jourabchi1, Manuel Benedetti and Giulia De Lorenzo. Agrobacterium tumefaciens-mediated introduction of the polygalacturonase inhibiting protein 2 (PvPGIP2) from Phaseolus vulgaris gene into sugar beet (Beta vulgaris L.). AJCS 6(8), 2012:1290-1297
Mohammadzadeh R., Motallebi M., and Zamani M.R. 2006. “Expression of β-1,3 glucanase gene from Trichoderma virens in BY-2 cell suspension”. 14th Iranian Biology Conference and the Second International Conference of Biology. 29-31 Aug. Tarbiat Modares University, Tehran, I.R. of Iran
LOCUS EF633614 2280 bp mRNA linear PLN 26-JUN-2007, DEFINITION, Hypocrea virens endo-beta 1,3-glucanase (bgnI) mRNA,ACCESSION EF633614
LOCUS EF633613 2345 bp DNA linear PLN 26-JUN-2007. DEFINITION Hypocrea virens endo-beta 1,3-glucanase (bgnI)gene, ACCESSION EF633613 VERSION  EF633613.1 GI: 149347124
Mohammadzadeh R¹., Zamani M.R¹., Motallebi M¹ and Bidmeshkipour A² (2004), Isolation, cloning and sequencing of Endo β-1,3 Glucanase gene from Trichodrma virens¹National ¹Institute for Genetic Engineering & Biotechnology (NIGEB), Tehran, Iran ²Biology Dept., Faculty of Science, Razi Univ., Kermanshah, Iran.

کتاب ها


تشویق ها


عضویت در مجامع علمی و انجمن ها


- انجمن ژنتیک ایران 
-انجمن بیوتکنولوژی ایران
- انجمن زیست شناسی ایران 
- انجمن ایمنی زیستی ایران

اختراعات


مقالات ارائه شده


مقالات چاپ شده در مجلات


تحقیقات


سوابق اجرایی


- نماینده دانشگاه در ستاد زیست فناوری ریاست جمهوری 
- مدیر گروه زیست شناسی دانشگاه مراغه (96/6/28 الی ادامه دارد)

علایق


کارگاه ها


آموزش


طرح درس


سایر


پروژه های تحقیقاتی


Current Research:
  • Targeted delivery of L-Asparaginase II into ALL cells using chitosan-based nanoparticles and studying the expression of apoptosis-related genes (M. Sc thesis-95)
  • Study of simultaneous effect of doxorubicin and miR-34a on induction of apoptosis in T-cell acute lymphoblastic leukemia (T-ALL) (M. Sc thesis-95)
  • Evaluation of pDNA-Loaded chitosan-based nanoparticles for targeted gene delivery to cancer cells toward development of DNA vaccines (M. Sc thesis-95)
  • Chimeric recombinant expression of S1 and HN antigens in Escherichia coli and their formulation by chitosan Nanocomposites toward development of a chimeric nanovaccine against Newcastle disease and infectious bronchitis virus of poultry (M. Sc thesis)
  • Optimizations of targeted gene delivery system into cancer cell based on  acid folic ligand/chitosan Nano composites/anti-cancer drug or gene (M.Sc thesis-95)
  • Analysis of apoptotic pathway genes expression in HL60 Cell Line exposed to Oreganum vulgare nanoparticles (M. Sc thesis - 94)
  • Silencing of bach1and Sail1 gene by small interfering RNA–mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in breast cancer cells (M. Sc thesis-93)
  • Evaluation of colorectal cancer p53 mutation in North West of Iran patients using non-insive method (M. Sc thesis)
  • Designs and constriction of targeted gene delivery system based on chitosan Nano composites (M. Sc thesis-93)
  • Isolation, cloning and expression of Aspergillus niger L-Arginase in Pichia pastoris and immobilization on chitosan nanocomposites (M. Sc thesis-93)
  • Study of mutations in the Androgen Receptor-LBD Gene in Males with Idiopathic Infertility (M. Sc thesis-93)
  • Optimizing the detection method of recombinant Soya and corn oils imported using PCR (M. Sc thesis-92).
  • Isolation, cloning and expression of Bacterial L- Asparaginase genes in Pichiapastoris/ pET system and immobilization in chitosan base nanocomposites (M. Sc thesis-92).
  • Study the association of VDR and NOD2 genes polymorphisms with Parkinson disease using PCR-RFLP techniques in Iranian population (M. SC thesis-91)
  • Molecular characterizations of S1 gene of avian infectious bronchitis virus isolated from layer flocks with nephropathy and urolithiasis in North-east of  Iran (M. Sc thesis - 91)

پروژه های تحقیقاتی خارج از دانشگاه


 
- Study of simultaneous effect of doxorubicin and miR-34a on induction of apoptosis in T-cell acute lymphoblastic leukemia (T-ALL)
(مشترک با دکتر بهزاد برادران - ایمونولوژی  از دانشگاه علوم پزشکی تبریز، رئیس مرکز تحقیقات ایمونولوژی  
 
Determining the prevalence of genes involved in biofilm formation in Acinetobacter baumannii isolates isolated from patients at hospitals in Tabriz- 
دکتر بهروز نقیلی - متخصص بیماری­های عفونی و گرمسیری از دانشگاه علوم پزشکی تبریز و  دکتر صفر فرج نیا- بیوتکنولوژی از دانشگاه علوم پزشکی تبریز